Transcriptional Regulation by Asf1: New Mechanistic Insights from Studies of the Dna Damage Response to Replication Stress
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چکیده
TRANSCRIPTIONAL REGULATION BY ASF1: NEW MECHANISTIC INSIGHTS FROM STUDIES OF THE DNA DAMAGE RESPONSE TO REPLICATION STRESS Laura V. Minard, Jessica S. Williams, Amelia C. Walker and Michael C. Schultz Department of Biochemistry, School of Molecular and Systems Medicine, Faculty of Medicine and Dentistry, University of Alberta, Edmonton, Alberta, Canada T6G 2H7 Current address: Laboratory of Molecular Genetics, National Institute of Environmental Health Sciences Research, NIH, DHHS, Research Triangle Park, NC 27709, USA Running head: Control of DNA damage response genes by Asf1 and H3 K56ac Address correspondence to: Michael C. Schultz, Tel: 780 492 9144; Fax: 780 492 0886; E-mail: [email protected] The abbreviations used are: KAT, lysine acetyltransferase; DDR, DNA damage response; ChIP, chromatin immunoprecipitation; HU, Hydroxyurea; MMS, methyl methanesulfonate; asf1N, amino acids 1-155 of yeast Asf1
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SWI/SNF and Asf1 Independently Promote Derepression of the DNA Damage Response Genes under Conditions of Replication Stress
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